Journal de toxicologie clinique
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Radical Scavenging Activities of Albumin-Copper Complex against Bromobenzene Induced Hepatotoxicity

Doaa Safwat Abdel-Magiud, Ahmed Y. Nassar, Ahmed R. Shatat and Ayman S. Mohamed

This study was performed to examine that copper-albumin complex can restore oxidative damage and cytotoxicity in induced by Bromobenzene (BB) in liver. Rats were divided into three groups. Group I served as control received corn oil only. Group II exposed to BB at a dose of 300 mg/Kg by weight, twice/week, orally, dissolved in corn oil for one month. Group III received BB as previous dose plus copper albumin- Serum total protein and albumin showed significant reduction while the activities of ALT and AST enzymes significantly increased in BB-treated group when compared to control. The antioxidant enzymes activities were found to be decreased in BB treated rats in contrast nitric oxide and lipid peroxidation levels were increased in comparison with normal control. Histopathology revealed that BB had a hepatotoxic effects represented by hepatitis and fatty degeneration. Nile blue positive stain showed lipofuscin and/or ceroid granules. Necrotic nuclei with disintegrated DNA stained with acridine orange. The treated rats with copper-albumin complex reversed the most of parameters to normal control.