Journal du métabolisme des médicaments et de la toxicologie
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Mechanism of Polygonum bistorta and Zingiber roseum Against Toxicity

Deepak Kumar Mittal, Alok Kumar Jena and Deepmala Joshi

The present study was carried out to observe the hepatoprotective effect and antioxidant activity of the aqueous extract of the roots of Polygonum bistorta (PB) (100 mg/kg) and Zingiber roseum (ZR) (100 mg/kg) in rats treated with carbon tetrachloride (0.15 ml/kg, i.p.). Extract of PB and ZR at the tested doses restored the levels of liver homogenate enzymes (glutathione peroxidase, glutathione-S-transferase, superoxide dismutase and catalase enzymes significantly. The activities of MTT assay significantly recovered the damage towards normal. This study shows that Zingiber roseum has a more liver protective effect in comparison to Polygonum bistorta and against carbon tetrachloride- induced hepatotoxicity and possess antioxidant activities and extracts exhibited moderate anticancer activity towards cell viability at higher concentration.