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Translational Medicine 2015: Subdivisions of regulatory T cells and their characters in allergy - Huiyun Zhang - Liaoning Medical University Huiyun Zhang

Huiyun Zhang

In recent years, it's recognized that immunity is controlled by regulatory T cell (Treg). Since essential pathophysiological vagaries of allergy are primarily caused by hyper responsiveness of system to allergens that obtains after birth, Tregs probable play important roles within the pathogenesis of allergy, predominantly in the sensitization phase. The aim of this study is to aim to classify subtypes of Tregs and summarize their roles in allergy. Tregs must contain natural Tregs (nTreg) counting inducible costimulator (ICOS) (+) Tregs, CD8(+) Tregs and IL-17-producing Tregs, interleukin (IL)-10-producing type 1 Tregs (Tr1 cells), inducible/adaptive Tregs (iTreg). These cells share some conjoint features as well as appearance of Foxp3, and secretion of inhibitory cytokine IL-10 and/or TGF-β. Moreover, it's obvious that Tregs likely pay to allergic conditions like airway inflammation and dermatitis, and plays a significant role within the conduct of allergy complete their actions on conquest of effector T cells and self-consciousness of initiation of mast cells and basophils. Modulation of functions of Tregs may provide a completely unique strategy to stop and treat allergic diseases.