Recherche immunitaire
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Role of Plasma Cytokines and Endotoxin in Patients with Acute Aortic Dissection

Firoj KM, Fa XE, Yu HB and Huang ZF

Objective: To analyze the role of plasma cytokines and endotoxin in patients with acute aortic dissection (AAD) in concluding prognostic effect. Material and methods: A total of 85 patients with acute aortic dissection were admitted in 2nd affiliated hospital of Zhengzhou university from January 2009 to November 2015. Patients were divided into death group and survival group. At the time of admission (T1), 12 hours after admission (T2), 24 hours after admission (T3), the plasma level of interleukin-6 (IL-6), interleukin- 10 (IL-10), tumor necrosing factor- alpha(TNF-α) and endotoxins were measured. Results: The plasma level of IL-6, TNF-α and endotoxins in death group at each time point were significantly higher than survival group (F group=3.194, 5.973, 9.156, P<0.05. There were significant difference of IL-6, TNF-α and endotoxins levels among three time points in two groups (F time=5.135, 11.548, 8.875, P<0.05. IL-6, TNF-α levels in the survival group at T3, IL-6 level in death group at T2, IL-6, TNF-α and endotoxins levels in the death group at T3 were significantly higher than T1, P<0.05. There was no significant difference in IL-10 level between two groups and among three time points (F group=1.674, F time=2.901, P>0.05. Conclusion: Plasma level of IL-6, TNF-α and endotoxin are increased in the acute aortic dissections showing the progressive development of AAD. Our findings in this study indicate the role of inflammation during AAD. The changing pattern of these markers can be used for diagnosis and prophylactic treatment of AAD.