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Recent Advances in Natural Product-Based NF‑κB Inhibitors as Anticancer and Anti-Inflammatory Agents

Arijit Nandi*, Anwesha Das

A large number of papers support the idea that the Nuclear Factor Kappa B (NF-κB) pathway can regulate the pathophysiological conditions of cancer, inflammation, and many diseases of the central nervous system. Surprisingly, for such an important transcription factor, little progress has been made in discovering the specific effects of natural compounds as inhibitors of the NF-κB pathway. A number of natural products and traditional medicines are widely used by people all over the world for various diseases for which the mechanism is unknown. Among this undiscovered domain, a large number of compounds were isolated and exhibited their regulatory activity on the NF-κB pathway.