Chimiothérapie : Libre accès
Libre accès

Abstrait

Possibility of the Strategic Treatment for Various Tumors using the Leukotriene Receptor Antagonist: Discussion Based on the Common Pathologic Findings that Mast Cells and Leukotrienes are Involved in the Development and Proliferation of Tumors

Masao Sugamata

The leukotriene receptor antagonist is indicated with a therapeutic drug of asthma and is one of the antiallergicagents. We found that mast cells and a leukotriene receptor commonly emerged for various malignant and benigntumors and proved that the allergic reaction was strongly associated with development and proliferation of tumors.And we experimented on the effect of treatment of the leukotriene receptor antagonist for spontaneous rat tumor andconfirmed the efficacy. Our data show a wide effect of this medicine and the fewer side effects and will cause adiscussion for the chemotherapy of the current malignant tumor. This commentary briefly summarizes about currentevidence and future prospect in the oncotherapy of the leukotriene receptor antagonist.