Journal de la leucémie
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Oral Hygiene Status and Selected Saliva Biomarkers in Children with Acute Lymphoblastic Leukaemia During Anticancer Therapy

Elzbieta Pels

Altered secretion of saliva and its changed composition in patients undergoing chemotherapy often results in oral mucosa pathologies. The aim of this study was to assess the impact of oral hygiene and the concentration of calcium, phosphate and magnesium ions in the saliva on developing oral mucositis in children with acute lymphoblastic leukaemia (ALL) during anticancer therapy. The study included 78 children, aged from 2 to 18 yrs suffering from ALL on anticancer therapy. The results of biochemical scores found that the concentrations of calcium, phosphate and magnesium ions in the saliva of children with ALL were affected. Oral hygiene condition and lower concentrations of selected biomarkers in the saliva in children with ALL during chemotherapy may affect the intensity of the pathological changes in the oral mucosa.