Journal de l'alcoolisme et de la toxicomanie
Libre accès

Abstrait

J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox™ Safety and Genotoxicity Analysis

Brice Gouvernet, Magaly Yvinec, Julie Catero4 and Pr Jean-Luc Viaux

The purpose of this paper is to study the existing relationships among alcohol-dependent persons between psychological distress and clinical features associated as it is their operation under the influence of alcohol or when n ‘not drinking. To do this we change the set of the DeRogatis” SCL90r by offering inpatient detoxification for a cure to respond in two modes: “when I drank” and “usually”. Using structural equation modelling allowed us to build and test a first model of the interactions between clinical dimensions and psychological distress when the person has been drinking and a second when the person is in its normal state. Despite as certain stability in the implied factors (anxiety, depression, psychosis, sensitivity, and obsession-compulsion), on one hand we can observe that the global severity index (GSI) is underlined by paranoid dimension and on the other had by phobic dimension. Although these facts are coherent with the clinical descriptions, this work should be reproduced among a larger sample.