Journal du syndrome de Down et des anomalies chromosomiques
Libre accès

Abstrait

Individuals with Down's Syndrome and Alzheimer's Disease: The Opportunities for and the Difficulties of Creating Preventive Therapies

Daniel Lerda

At a relatively early age, individuals with Down's syndrome (DS) are at high risk of contracting Alzheimer's disease (AD). This elevated risk is not observed for causes other than DS in individuals with intellectual disabilities, and for this reason it is unlikely to be attributed to non-specific symptoms of neurodevelopmental illness, but instead a direct product of DS genetics (trisomy 21).