Journal de protéomique et bioinformatique
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Identification of a Point Mutation Causing Splitting of Antigenic Domain in M1 Protein of H5n1 Strain from 2006 Outbreak in India

Tamanna Anwar and Asad U Khan

Influenza virus shows great variation in virulence. Numerous influenza virulence studies have sought to define the roles of each viral gene in disease production.To understand M1 protein it is necessary to study the functional properties of its distinct domains. Until now, in silico studies on M1 protein of Influenza A H5N1 virus are limited. The purpose of this study was to analyze the antigenic domains of the M1 protein of H5N1 strains found epidemic in Navapur (ABG88883) and Jalgaon, India (ABJ96491) during 2006 outbreak, and to identify antigenic differences between M1 proteins of other strains from different origin. It was noticed that the splitting of antigenic domain within position 48 to 69 of M1 was due to point mutation at position 59 from Isoleucine to Methionine. The antigenic regions identified here might be important for the development of diagnostic test for Influenza A H5N1 infection showing discrimination between different antigenic types of M1 protein of Influenza A H5N1.