Biochimie & Pharmacologie : Libre accès
Libre accès

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Heamatobiochemical Alterations Induced by Carbamazepine and Phenytoin: Mini Review

Hadiza Aliyu*, Joseph O Ayo, Suleiman F Ambali, Muhammed U Kawu, Tagang Aluwong, Tavershima Dzenda, Lukuman S Yakub and Peter O Yusuf

This review was carried out to conduct a literature survey of the effects of anticonvulsants carbamazepine (CBZ), phenytoin (PHT) and their combination on haematological and serum biochemical parameters. CBZ and PHT are among the oldest AEDs and usually the first line of treatment in epilepsy, being prescribed alone or sometimes in combination for retractable epilepsy. AEDs have been associated with different side effects which could be deleterious to the haemopoietic, nervous and/or hepatic systems. However, these effects may subside with the discontinuation of the medication(s). Side effects are prominent with the older AEDs such as CBZ, PHT, valproic acid (VPA) and phenobarbital (PB).