Journal du syndrome de Down et des anomalies chromosomiques
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Detecting the Early Signs of Cognitive Decline

Ivan Kanev

Alzheimer's disease (AD) is a neurodegenerative brain disorder that is a primary cause of cognitive decline and dementia, and its incidence and prevalence are rising in both urban and rural areas. Despite extensive study over the previous thirty years, no effective drug is currently available. Amyloid deposition and neurofibrillary tangles are neuropathological markers of Alzheimer's disease, although their presence does not fully explain the disease. The pathophysiology of the illness A peptide, the proteinaceous precursor of brain amyloid plaques, has just been discovered. As an antimicrobial factor, it has been proposed. Virus and/or bacterial infections have been demonstrated to cause cancer in recent studies.