Endocrinologie et syndrome métabolique
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Anti-Inflammatory Effects of Dietary Antioxidants in Patients with Coronary Artery Disease

Mahdieh Niknam, Zamzam Paknahad, Ahmadreza Baghestani and Mohammad Hashemi

Background: Atherosclerosis, with its major manifestation, Coronary Artery Disease [CAD] is a chronic inflammatory disease. Dietary antioxidant intakes favorably effect on inflammatory responses.

Objective: This study was conducted to examine the association between dietary antioxidants including vitamin E and vitamin C with inflammatory markers, IL-6 [Interleukin 6] and hs-CRP [high sensitivity C-reactive protein], in CAD patients among Iranian population.

Methods: This hospital-based cross-sectional study was conducted in Sina Heart Hospital, Isfahan, Iran in 2012. This study included 150 men Patients aged ≥45 years with first ever symptomatic CAD that had been confirmed by angiography. A semi-quantitative food frequency questionnaire was used to assess the usual intakes of dietary vitamin E and C.

Results: The mean intake of vitamin E and C in our study population was 0/018 ± 0/0018 g/d and 0/081 ± 0/0049 g/d, respectively. After adjustment for potential confounders, vitamin E was inversely significantly related to hs-CRP [P=0.004] and IL-6 [P=0.022] concentrations. Intake of vitamin C was inversely significantly related to plasma IL-6 concentration [P=0.042], but not hs-CRP [P=0.17].

Conclusion: Our finding suggests that these dietary antioxidants, vitamin E and C, were significantly related to plasma inflammatory markers in CAD patients.