Journal de toxicologie clinique
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Antidiabetic Activity of Newly Formulated Oral Polyherbal Tablets in Alloxan Induced Diabetic Rats

Brijyog, Ashish Sarkar, Sushil Kumar and Shweta Verma

Anacardium occidentale, Aegle marmelos and Achyranthes aspera are the medicinal plant and used for the treatment of diabetes mellitus. There is major challenge in bioavailability of herbal products when administered in raw form, and it can be overcome in the form of polyherbal tablets. In the present study polyherbal tablets were prepared using hydroalcoholic extracts of Anacardium occidentale (bark), Aegle marmelos (leaves) and Achyranthes aspera (aerial parts) by dry granulation method for the management of diabetes. Tablets were prepared and evaluated by using weight variation, hardness, and friability and disintegration time. The optimized formulation was investigated the antidiabetic activity in Alloxan-induced diabetic albino rats. Fasting blood glucose level and changes in body weight were measured on days 0, 8 and 15. At the end of 15 day, serum lipid profile and protein were assessed. The finding of weight variation, hardness, friability and disintegration time of polyherbal tablets were within acceptable pharmacopoeial limits. Among six formulations prepared (F1 to F6), F1 showed appreciable results, and subjected for antidiabetic activity. After the administration of F1, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered with improvement in body weight and lipid profile. From the results, it has been concluded that the prepared polyherbal tablets has the potential to act as an antidiabetic drug.