Chimie organique: recherches en cours
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An Expedient General Synthesis of Quinolino and Pyrrolocycloocta[b] Indoles

Leena Vairavelu et Rajendra Prasad KJ

A one pot solvent free acid catalyzed Friedlander synthesis of quinolinocycloocta[b]indoles (2 and 3) and pyrrolocycloocta[b]indoles (4) has been accomplished through the condensation reaction of various 5,7,8,9,10,11-hex ahydrocycloocta[b]indole-6-ones (1) with amino benzophenones and glycine respectively. The reaction condition was optimized for the synthesis of quinolinocycloocta[b]indoles. This is the first general synthesis of pyrrolocycloocta[b] indoles.