Journal des syndromes génétiques et de la thérapie génique
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Therapeutical Potential of Microvesicles in Cardiovascular Diseases

Yasukatsu Izumi

MicroRNAs (miRNAs) are small, highly conserved, non-coding RNA molecules that regulate hundreds of gene expression and thereby, affect global changes in the physiology of cells. Extracellular miRNAs are packaged with proteins or wrapped in microvesicles including microparticles, exosomes, and apoptotic bodies. These vesicles are potential candidates for therapeutical targets. Recent studies have indicated that microvesicles have the roles of deleterious information in blood vessel wall under pathological situations such as hypertension, myocardial infarction and metabolic syndrome, whose diseases are results of the endothelial dysfunction. However, the role of endothelial cells-derived microvesicles is unknown. Uncovering the difference and potential role of these microvesicles in endothelial cells is emerging