Journal des probiotiques et de la santé
Libre accès

Abstrait

The Probiotic BIOHM Improves Nutrient Absorption by Disrupting Gastrointestinal Biofilms

Ghannoum M, Ghannoum A, Hager C, Retuerto M, Isham N, McCormick TS

Aim: To demonstrate the ability of a probiotic supplement (BIOHM) to disrupt pathogenic gastrointestinal biofilms, thus enhancing nutrient absorption.

Methods: A filter insert model using Caco-2 cells to mimic an intestinal monolayer was employed to determine the ability of BIOHM to disrupt a mixed species (Candida tropicalis, Escherichia coli and Serratia marcescens) biofilm known to occur in patients with Crohn’s disease. Penetration of vitamin C and casein as representative of vitamins and proteins, respectively, was then measured.

Results: Application of BIOHM led to a significant increase in casein penetration through the Caco-2 cell epithelial monolayer in the absence of biofilms (p value<0.0001). Additionally, the combination of mixed species biofilms grown on a Caco-2 cell monolayer with BIOHM filtrate resulted in higher penetration of vitamin C and casein through the monolayer compared to untreated controls.

Conclusion: Our in vitro data indicates that the combination of ingredients in the BIOHM probiotic may enhance nutrient permeability, thus leading to increased overall absorption of proteins and vitamins.