Journal de recherche clinique et expérimentale en dermatologie
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Psoriatic Arthritis: The Link between Cardiometabolic Disease and Inflammatory Activity

Jose Andres Lorenzo Martin

Background and objective: Psoriatic arthritis is accompained by several cardiometabolic comorbidities. Obesity causes a low-grade systemic inflammation and is a negative predictor of treatment response. We wanted to evaluate if there are interactions between metabolic status, inflammatory parameters and disease activity; and whether metabolic or cardiovascular diseases have any association with the reduction of the inflammatory burden by treating the psoriatic arthritis.

Methods: we have carried out a cross-sectional descriptive study of 160 patients with psoriatic arthritis. Socio demographic, clinical and analytical variables were collected, as well as the presence of dactylitis and enthesitis; and HAQ, DAPSA and Minimal Disease Activity criteria. Chi-square test and the H of Kruskall Wallis were used to carry out comparisons, considering p<0.05 as statistically significant. To establish correlations, Pearson correlation coefficient was used.

Results: BMI and waist circumference correlate with CRP and ESR (significance: <0.05) although the correlation strength is low (Pearson<0.4), but there is no such relationship with DAPSA or meeting MDA criteria. Using biologic therapies is associated with a lower prevalence of cardiovascular events (p=0.047; OR: 0.12, CI 95%: 0.01-0.9) and enthesitis (p=0.008; OR: 0.3, CI 95 %: 0.16-0.56); and normal levels of CRP (p=0.029; OR: 0.25, CI 95%: 0.07-0.87) and ESR (p=0.024; OR: 0.36, CI 95%: 0.16-0.82) when comparing to conventional therapies.