Journal des syndromes génétiques et de la thérapie génique

Journal des syndromes génétiques et de la thérapie génique
Libre accès

ISSN: ISSN: 2157-7412

Abstrait

Novel Inflammasomes and Type II Diabetes, Intestinal Inflammation and Psoriasis as Newly Inflammasome-Related Diseases

Michael C. Heymann and Sigrun R. Hofmann

Inflammasomes are multiprotein complexes representing an activating platform for caspase-1. This enzyme processes the cytokines IL-1β, IL-18 and others into their bioactive variants leading to an inflammatory cascade. Mutations responsible for defects in inflammasome regulation cause severe autoinflammatory disorders.
 
This review provides a short summary of new insights in the autoinflammatory field including the association of inflammasomes to diabetes, intestinal inflammation as well as psoriasis and communicates the ideas of two novel inflammasomes, recently discovered.

Clause de non-responsabilité: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été révisé ou vérifié.
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