Journal de protéomique et bioinformatique
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Mitochondrial Haplogroups Associated with Japanese Centenarians, Alzheimer’s Patients, Parkinson’s Patients, Type 2 Diabetes Patients, Healthy Non-Obese Young Males, and Obese Young Males

Shigeru Takasaki

There are strong connections among mitochondria, aging, and a wide variety of diseases. In this paper, the relations between eight classes of Japanese people-96 centenarians, 112 semi-supercentenarians (over 105 years old but less than 116 years old), 96 Alzheimer's disease (AD) patients, 96 Parkinson's disease (PD) patients, 96 type 2 diabetes (T2D) patients, 96 T2D patients with angiopathy, 96 healthy non-obese young males and 96 healthy obese young males-and their mitochondrial single nucleotide polymorphism (mtSNP) frequencies at individual mtDNA positions of the entire mitochondrial genome were examined using the radial basis function (RBF) network and a modified RBF method. New findings of mitochondrial haplogroups were obtained for individual classes. The centenarians were found to be associated with the haplogroups D4b2a, B5b, and M7b2; the semi-supercentenarinas with B4c1a, F1, B4c1c1, B4c1b1, and M1; the AD patients with G2a and N9b1; the PD patients with N9a, G1a, B4e, and M7a1a; the T2D patients with D4b2b, M8a, and B5b; the T2D patients with angiopathy with N9a2, D4b1, and G2a; the healthy non-obese young males with D4g, N9a, D4b2b, and B4b/d/e; and the healthy obese young males with M7b2, D4b2b, B4c1, and M7a1a. These results are different from the previously reported haplogroup classifications. As the proposed analysis method can predict a person's mtSNP constitution and probabilities of becoming a centenarian, AD patient, PD patient, or T2D patient, it may be useful in the initial diagnosis of various diseases or longevity.