Journal des syndromes génétiques et de la thérapie génique

Journal des syndromes génétiques et de la thérapie génique
Libre accès

ISSN: ISSN: 2157-7412

Abstrait

Helper-Dependent Adenoviral Vectors

Amanda Rosewell, Francesco Vetrini and Philip Ng

Helper-dependent adenoviral vectors are devoid of all viral coding sequences, possess a large cloning capacity, and can efficiently transduce a wide variety of cell types from various species independent of the cell cycle to mediate long-term transgene expression without chronic toxicity. These non-integrating vectors hold tremendous potential for a variety of gene transfer and gene therapy applications. Here, we review the production technologies, applications, obstacles to clinical translation and their potential resolutions, and the future challenges and unanswered questions regarding this promising gene transfer technology.

Clause de non-responsabilité: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été révisé ou vérifié.
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