Journal des maladies infectieuses et de la médecine préventive
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Epidemiology, Viral Pathogenesis, Host-Immune Response and PotentialVaccine Trial for the Treatment of SARS-CoV-2 Infection

Abbas Abel Anzaku, Olasinbo Balogun, Akwashiki Ombugadu, Nneka Egbuchulam, Ibrahim Yusuf,Ifeanyichuku Odoh, Nurudeen Olalekan Oketade, Akpason Esla Amre

Background: The current outbreak of COVID-19 caused by SARS-CoV-2 raised fundamental public health concerns as its emergence has been marked the third introduction of a highly pathogenic coronavirus into the human population after SARS-CoV and MERS-CoV in the twenty-first century. Recent advancement of SARS-CoV-2 infection revealed mechanism of immune evasion during the pathogenesis. Hence, this study reviewed available literature on epidemiology of SARS-CoV-2, viral pathogenesis, host immune response to the infection and potential vaccine trial for the treatment of the infection.

Methods: Systematic review technique was used for this study.

Results: This study provides an immunological insight i nto the SARS-CoV-2 infection for better understating of the virus and as well as the strategies for use in combating the disease.

Conclusion: This predictive view may help in designing an immune intervention or preventive vaccine for COVID-19 in the near future.