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Effect of Imidacloprid and Tetraconazole on Various Hematological and Biochemical Parameters in Male Albino Rats (Rattus Norvegious)

Mostafa A Abbassy, Mamdouh A Marzouk, Hoda M Nasr and Awatef SM Mansy

This study was carried out to investigate the toxicity of imidacloprid and tetraconazole in male rats given daily oral doses of these pesticides (for 30 days). Which equal to those residues found in and on cucumber fruits after zero time, (24 hour after application) as well as two doses which equal 0.1, 0.125 of the LD50 value for each pesticide? These doses were (0.943, 0.365, 45, 56.25 mg/kg) for imidacloprid, and (0.174, 0.104, 124.8, 156 mg/kg) for tetraconazole, respectively.Results indicated that imidacloprid and tetraconazole residues on and in cucumber fruits after one hour and 24 hour from the last spray did not cause any significant effects on the activities of AST, ALT, GGT, LDH and ALP enzymes. There is no significant difference on the levels of creatinine, uric acid, total protein, albumin and glucose in the serum of treated rats. There is no effect on Packed Cell Volume (PCV), Red Blood Cell Counts (RBC’s), haemoglobin (Hb) and White Blood Cell Counts (WBC’s) in the blood of treated rats. Also doses equal to the residues did not cause any harmful effect on concentrations of AChE, T3, T4, TSH and testosterone hormone. The aforementioned results of this part of study indicated that the neonicotinoid insecticide, imidacloprid, and the fungicide tetraconazole, can induce a variety of alterations in the activities of AST, ALT, GGT, LDH and ALP enzymes and the levels of creatinine, uric acid, total protein, albumin and glucose in the serum of treated rats also the concentrations of AChE, T3, T4, TSH and testosterone hormone at higher doses which equal to 0.125 and 0.1of the LD50value for each pesticide. The severity of their action depends entirely on the level of the given doses and the type of the tested pesticides.