Journal des probiotiques et de la santé
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A Novel Bacteriocins Inhibited More Number of Pathogens: A Review

Mojess Vadlapudi*

Bacteriocins are a diverse group of bacterial antimicrobial peptides. Bacteriocins containing a string of amino acids, hence these are called as a proteins, these are produced by wide range of probiotics. Bacteriocins having the ability to inhibit the growth of disease causing microorganisms. Bacteriocins destruct the plasma membrane potential through leakage of cellular contents (ions, ATP), and formation of a pore in the plasma membrane. Regarding to bactibase website from 1992 to until now 442 bacteriocins were isolated, purified and characterized, in these 442 only few bacteriocins having the ability to show antagonistic activity on high number of disease causing microorganisms. In this review mainly focus on which bacteriocins are produced from which bacterial species and what are the methods were used to purify that bacteriocins. Many researchers were used ammonium sulphate precipitation method for purification of bacteriocins, in this review several methods were discussed for purification of a novel bacteriocins. For example variacin it is a bacteriocin, it was isolated from the Micrococcus variants, it have the ability to show antagonistic activity on 26 disease causing microbes that are Clostridium botulinum, Bacillus cereus, Enterococcus faecalis, etc. In this review we discussing about only seven bacteriocins about their purification methods, produced organisms and inhibitory activity.