Journal de recherche clinique et expérimentale en dermatologie
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Treatment for Striae Alba with Poly-l-lactic Acid: A Pilot Study

Marisa Cunha

Background: Striae distensae is a common dermatological impairment leading to a therapeutic challenge. Many treatments are available; however, these treatments usually incur risks of hyperpigmentation and bad scar healing related to the phototype of the patient. Poly-L-Lactic Acid (PLLA) could improve the area due to its biostimulatory properties.

Objective: To demonstrate the improvement of white striae after PLLA application.

Method: This was a pilot study conducted in adults with symmetrical and bilateral white striae, 1 mm-4 mm wide, located on the gluteal or abdominal region. Photographs for register of the improve, a questionnaire about adverse events, and ultrasonography, to analyze the skin thickness of the striae area pre and post application, were done before and after 3 and 6 months of the last application of PLLA. Three monthly applications were performed in the affected area, using 0.04 ml of the product retro-injected into the deep dermis and superficial hypodermis at the center of each square. The area is 10 cm × 10 cm around 64 squares for application.

Result: All patients have described an improvement in the area, with minimal adverse events. Ultrasonography images have shown an increase in the dermal thickness in the striae area.

Conclusion: PLLA application showed to be a good alternative to treat striae in abdominal and gluteal area.