Journal d'ophtalmologie clinique et expérimentale
Libre accès
ISSN: 2155-9570
ISSN: 2155-9570
Dongwei Lai, Baiqi Liu, Linqing Xiong, Yiwei Yin, Xiaobo Xia, Wenyi Wu
Ocular angiogenesis is an important contributor to many vision-decreasing diseases, such as retinopathy of prematurity, proliferative diabetic retinopathy, as well as age-related macular degeneration. Understanding the molecular mechanism of angiogenesis has advanced the development of effective medicine in preventing ocular neovascularization. Phosphoinositide 3 kinases (PI3Ks), a main downstream of growth factors, are a family of lipases that are evolutionarily conserved in their ability to regulate cell growth and survival as well as migration and metabolism. Much evidence showed that it also plays a significant role in angiogenesis. Here, we review the distinct functions of class I PI3Ks in the canonical angiogenic pathway and its potential mechanism as a novel therapeutic target in ocular pathological angiogenesis.