Journal de la science cellulaire et de la thérapie
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Abstrait

The Role of Bile Acids in the Liver and Biliary Diseases

Yuxue Gao, Qiqi Ning, Mengxi Jiang*, Dexi Chen*

Bile acids are critical endocrine elements of the signalling pathway regulating important pathophysiological processes in the diverse liver and biliary diseases. This mini-review summarizes the interplay between bile acids, bile acids activated receptors, and host-microbiome in hepatic and biliary disorders, such as non-alcoholic fatty liver disease, cholestatic liver disease, and HBV-related liver disease, and discusses potential BAs-based therapeutic strategies for these diseases.