Journal des soins pharmaceutiques et des systèmes de santé
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The Role of Asthma Exercise on Inflammation and Quality of Life in Atopy Asthmatic Persistent

Rahmaya Nova Handayani , Faisal Yunus

Background: Asthma is a chronic inflammation of the respiratory tract involves the interaction of several cell types and mediators that will cause asthma symptoms. This study aims to study the effect of asthma exercise on interleukin, immunoglobulin and quality of life in autopsy asthmatic persistent.

Methods: This research is an experimental study with pre-post-test group design. 39 subjects were taken based on medical records at Prof. Dr. Margono Soekarjo Regional Public Hospital of Purwokerto with inclusion criteria. Interleukin 10 (taken from peripheral blood mononuclear cell with supernatant) and immunoglobulin E (blood plasma) test were done by ELISA. Quality of Life parameter used Asthma Quality of Life Questionnaire (AQLQ). All parameters were tested before and after doing asthma exercise for 4 times per week in 8 weeks with duration of 60 minutes. The analysis used was Wilcoxon and spearman analysis.

Results: There was a significant effect before and after asthma exercise increasing interleukin 10 with p value: 0.000; decrease immunoglobulin E with p value:0.001 and quality of life with p value:0,000. There was no correlation between the increase of interleukin 10 and the quality of life with p value: 0.063; no correlation increase interleukin 10 and decrease immunoglobulin E with p value: 0.280; no correlation between decrease immunoglobulin E and quality of life with p value 0.206.

Conclusion: Asthma exercise can increase interleukin 10 and quality of life and decrease immunoglobulin E levels. However, there was no correlation between the increase levels of interleukin 10, decrease immunoglobulin E and increase quality of life.