Journal d'immunologie clinique et cellulaire
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Abstrait

The LEP G-2548A Polymorphism is not Associated with Breast Cancer Susceptibility in Obese Western Mexican Women

Myra Judith Garcia-Robles, Adrian Daneri Navarro, Susana del Toro Arreola and Mary Fafutis Morris

Breast cancer incidence and the prevalence of obesity have considerably increased in Mexican women. The LEP G-2548A polymorphism has been associated with obesity and breast cancer risk in several ethnic populations. We hypothesize that G-2548A LEP polymorphism could be associated with breast cancer risk in women Mexican population. A total of 319 women were included in this study, 130 breast cancer patients and 189 control women. The data collected included anthropometric measurements and menopausal status, and a blood sample was obtained to evaluate SNPs using a PCR-RFLP analysis. No statistically significant associations were identified between breast cancer risk and the LEP G-2548A polymorphism in obese or normal-weight subgroups regardless of menopausal status. Our findings suggest that the LEP G-2548A polymorphism is not associated with breast cancer risk in obese western Mexican women. Our results indicate that, for western Mexican women, the LEP G-2548A polymorphism does not affect breast cancer susceptibility in obese or normal-weight subgroups regardless of menopausal status.