select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='12195' and ad.lang_id='5' and j.lang_id='5' and vi.lang_id='5' The Influence of Tissue-Specific Glucocorticoid System on th | 12195
Recherche immunitaire

Recherche immunitaire
Libre accès

ISSN: 1745-7580

Abstrait

The Influence of Tissue-Specific Glucocorticoid System on the Inflammatory Microenviroment: A Mini-Review

Anna Bazsó, Ágnes Szappanos, Gyula Poór, Yehuda Shoenfeld and Emese Kiss

Glucocorticoids have been belonged to the most widely and commonly used immune modulatory drugs in autoimmune and inflammatory conditions. The anti-inflammatory and immune suppressant mechanisms have been described. However, the glucocorticoids have paracrine and autocrine manner, acting at local tissue level and that is called as “tissue-specific” glucocorticoids. Those have a significant role in the development of inflammation. The glucocorticoid receptors, the sensitivity for glucocorticoids and the hypothalamic-pituitary-adrenal (HPA) axis are associated strongly in the development, treatment and outcome of the inflammatory diseases. Dysregulation of the immune system and the endogenous glucocorticoid system may contribute to the pathogenesis of chronic autoimmune and inflammatory diseases.

Clause de non-responsabilité: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été révisé ou vérifié.
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