Wenbin Yu, Zehan Jia, Yu Yang, Wenwen Zheng, Zixiao Wang, Xue Dong, Xing Zhang, Fenju Qin*
In recent years, the Cerium Oxide Nanoparticles (CeO2 NPs) will be used more and more widely, and their effects were also be concerns about on human health, particularly on the reproductive system. The previous studies have indicated that the testicles and sex hormones in males were be damaged by CeO2 NPs with long-term exposure. The effects of CeO2 NPs with different physical and chemical parameters, including size, shape, and surface coating about on male reproductive toxicity are explored in this study. This study analyzes the toxic effects of CeO2 NPs on male reproduction from the aspects of germ cells, sperm structure, blood-testis barrier, pituitary gonadotropins, and epididymis. Those findings will provide a theoretical basis and scientific evidence for the use of CeO2 NPs in the future.