Journal de pharmacie appliquée
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Abstrait

Synthesis Characterization and Biological Influence of Some Newly Synthesized Mix ligand Chelates

Pandya DR

Objective: A series of mixed ligand chelates of d10 were synthesized expending 3TC a potent nucleoside analogue and ACV, is a guanosine analogue antiviral drug.

Methods: The synthesized chelates were characterized by IR, Mass spectra, TGA analysis and Elemental analysis and were evaluated for their anti-fungal activity against a panel of two pathogenic fungal strains namely, Aspergillus niger, and Candida albicans by Broth-dilution method, antibacterial activity against E. coli, P. aeruginosa, S. aureus, S. pyogenus.

Results: All the compounds showed significant inhibitory activity against the microorganism. Anti-bacterial activity was determined using Ampicillin as a standard and antifungal activity was determined using standard Greseofulvin.

Conclusion: Out of all the chelates, the chelate of Cd2+ exhibited promising antimicrobial activity as a whole.