Journal d'ophtalmologie clinique et expérimentale
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Subconjunctival Bevacizumab Injection for Corneal Neovascularization in Interstitial Keratitis

Anchal Thakur, Amit Gupta and Sabia Handa

We describe the use of subconjunctival Bevacizuamb as an adjunct in the treatment of viral interstitial keratitis in a 17-year-old boy. He presented with a 3 months history of gradually progressive diminution of vision. The presenting visual acuity was 20/120 in the right eye and counting fingers close to face in the left eye. Examination revealed bilateral disc shaped stromal edema with leash of blood vessels entering the superior quadrant of the cornea. Subconjunctival injection of 0.1 mL (2.5 mg) of commercially available Bevacizumab (100 mg/4 mL; Avastin) was given under topical anesthesia along with initiation of topical steroids in the form of Betamethasone 0.1%. After 2 weeks of injection there was a remarkable reduction in corneal edema as documented by AS-OCT with improvement in visual acuity. We report here our experience with subconjunctival injection of bevacizumab for corneal vascularization in a patient with interstitial viral keratitis.