Anesthésie et recherche clinique
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Stress Response to Total Abdominal Hysterectomy under General Anesthesia in Type 2 Diabetic Subjects

Kawsar Sardar, Hafizur Rahman M, Abdur Rashid M, Omar Faruque M, Liaquat Ali, Shahera Khatun UH and Mesbahuddin Iqbal K

Aims: This study was designed to investigate the hemodynamic alteration and changes of glycemic, cortisol and electrolytes status in total abdominal hysterectomy of type 2 diabetic subjects under general anesthesia.

Subjects and method: Fourty subjects under general anesthesia for total abdominal hysterectomy were recruited and thrice blood samples were collected from each subject, before anesthesia (PT0), 10 minutes after incision (PT1) and 10 minutes after extubation (PT2). Plasma glucose was measured by glucose-oxidase method, serum C-peptide and serum cortisol by chemiluminescence’s based ELISA technique (Immulite, USA). Serum electrolytes were measured by Dry Chemistry method (DT-60, USA)

Results: All the subjects were hemodynamically stable during surgery. Plasma glucose increased significantly in PT2. Serum cortisol was significantly higher in PT1 and PT2 than PT0.

Conclusions: Total abdominal hysterectomy under general anesthesia in well controlled type 2 diabetic subjects is accompanied by a hyperglycemic response which results from rise of insulin antagonists like cortisol.