Journal des soins pharmaceutiques et des systèmes de santé

Journal des soins pharmaceutiques et des systèmes de santé
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ISSN: 2376-0419

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Stability Indicating RP-HPLC method Development and Validation of Salicylic Acid in Choline Magnesium Trisalicilate (Trilisate) Tablets

Pushpa Kumari K, Gowri Sankar, P. Sowjanya and S. Madhubabu

A stability indicating RP-HPLC method was developed and validated for the determination of Salicylic acid in Trilisate tablets using Xorabax XBD C18 column (150 × 4.6 mm, 5 μm) with mobile phase consisting of Phosphate buffer (pH 3.0), methanol (80:20 v/v) with a flow rate of 1ml/min. Detection was carried out at 230 nm. Retention time was found to be 4.6 min. Linearity was observed over the concentration range of 5-30 μg/ml (R2=0.999) with regression equation y=30.55x+5.302. Salicylic acid was subjected to stress conditions including acidic, alkaline, photolysis and thermal degradation. The drug is more sensitive towards alkaline degradation. The method was validated as per ICH guidelines.

Clause de non-responsabilité: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été révisé ou vérifié.
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