Chimiothérapie : Libre accès
Libre accès

Abstrait

Signification of Proteins P-53 Isoforms in a CLL

Aurelian Udristioiu, Delia-Nica Badea

In the past few years has used the technique for analyzing deletions of genes, its rearrangements, crossreactivity or multiplications in human genome affected of a variety genetic diseases. Was proved, the best techniques in the investigation of malignant lymphocytes are the Flow Cytometry, Elisa, ICT and Fluorescence in situ hybridization (FISH). Last method, FISH is used as an alternative to chromosomal banding, a conventional application in molecular medicine and can detect the chromosomal rearrangements and complexes of different genes in malignant diseases, like chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia, (ALL), or multiple myeloma (MM). Identification of P53 gene deletions and mutations in regions of chromosome 17 in hematological malignancies is important because these mutations have an impact on the clinical management of patients