Journal de toxicologie clinique
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Serial EEG changes in Low-Dose Baclofen Intoxication

Han Uk Ryu*, Hong Jin Kim, Hyun Goo Kang, Byoung Soo Shin

Baclofen, a derivative of the neurotransmitter γ-aminobutyric acid, is widely used to treat adjuvant pain and skeletal muscle spasms. Common side effects of baclofen can cause dizziness, drowsiness, or weakness, in addition to serious central nervous system problems such as loss of brain stem reflex, comatose mentality, myoclonic jerk, and seizures. Several cases have reported that baclofen intoxication is provoked by high overdose ingestion in a short period. We report two cases of serial EEG changes in low-dose baclofen intoxication that showed burst and suppression patterns and eventually returned to normal EEG in correlation with clinical improvement.