Journal de protéomique et bioinformatique
Libre accès

Abstrait

Role of Phosphoproteomics in Protein Activity

Myron R Szewczuk

Phosphoproteomics is a branch of proteomics that searches for, catalogues, and describes proteins with phosphate groups as a posttranslational alteration. Phosphorylation is an important reversible change that controls protein activity, subcellular localization, complex formation, protein degradation, and so cell signalling networks. With all of these findings, it's believed that 30% to 65% of all proteins are phosphorylated, with some being phosphorylated numerous times. In comparison to expression analysis, phosphoproteomics adds two more levels of data. Because a change in phosphorylation status usually invariably reflects a change in protein activity, it provides indications as to which protein or pathway may be activated. While phosphoproteomics will substantially increase our understanding of the amount and types of phosphoproteins, its most promising use is the quick investigation of complete phosphorylation-based signalling networks.