Recherche immunitaire
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Recent Progresses for Computationally Identifying N⁶-methyladenosine Sites in Saccharomyces cerevisiae

Kuo-Chen Chou

N⁶-methyladenosine (m⁶A) plays critical roles in a broad set of biological processes. Knowledge about the precise location of m⁶A site in the transcriptome is vital for deciphering its biological functions. Although experimental techniques have made substantial contributions to identify m⁶A methylations, they are still labor intensive, costly and time consuming. As good complements to experimental methods, in the past few years, a series of computational approaches have been proposed to identify m⁶A sites in Saccharomyces cerevisiae. In order to facilitate researchers to select appropriate methods for identifying m⁶A sites, it is necessary to give a comprehensive review and comparison on existing computational methods. In this review, we summarized the current progresses in computational prediction of m⁶A sites and also assessed the performance of computational methods for identifying m⁶A sites on an independent dataset. Finally, challenges and future directions of computationally identifying m⁶A sites were presented as well. Taken together, we anticipate that this review will provide an important guide for future computational analysis of m⁶A and other RNA modifications.