Chimiothérapie : Libre accès
Libre accès

Abstrait

Prevalence Multi-Resistant Bacteria in Hospital N'djamena, Chad

Bessimbaye Nadlaou,Tidjani Abdelsalam, Ndoutamia Guelmbaye , Kerah Hinzoumbé Clement  And Barro Nicolas

Antibiotic resistance is a phenomenon as old as the advent of antibiotics. Today, often of synthetic origin and produced by humans, antibiotics are from natural substances produced by fungi but also bacteria to defend against other bacteria. The first who learned to synthesize antibiotics developed at the same time the means to protect themselves. In assessing the prospects for the emergence of multi-resistant bacteria (BMR) in hospitals in Chad, samples of biological products for patients from different departments of the General Referral Hospital (HGRN) were examined for Search multi-resistant bacteria. 1,285 patients whose average age was 35.5 ± 14 years were included in this study. Isolation of bacteria was made after seeding of organic products on the following agar media: Hektoen, Mac Conkey, CLED, Chapman, Mueller-Hinton (MH) agar and polyvitex. The biochemical identification and antimicrobial susceptibility of bacteria were performed using the compact PLC VITEK® 2TM 15 to HGRN laboratory. Of the 1285 cultures analyzed, 328 (25.25%) were positive for bacterial infection. Of the 328 bacteria isolated and identified, 66 have submitted multiresistant phenotypes to different families of antibiotics for a prevalence rate of 20.12%. Of the 66 multiresistant bacteria, 44 (66.67%) strains of bacteria presented the multidrug-resistant phenotype to several families of antibiotics and 22 strains (33.33%) were only resistant to beta-lactams by producing beta lactamase extended spectrum (ESBLs) (significant difference p ≥ 0.001). This study suggests a disturbing trend in the emergence of multi-resistant bacteria in Chad and therefore should prompt appropriate corrective reactions.