Journal d'immunologie clinique et cellulaire
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Potential Relationship between Recent COVID-19, Autoantibody Profile, and Outcomes of Assisted Reproductive Technology Cycles in Non-Vaccinated Women

Nataliya V. Dolgushina1,2, Irina V. Menzhinskaya1*, Daria M. Ermakova1, Natalia A. Frankevich1, Valentina V. Vtorushina1, Gennady T. Sukhikh1,2

The observational prospective study included 240 women aged 18-40 years without systemic autoimmune diseases who applied for infertility treatment using ART. Patients were divided into two groups: group 1-105 patients without a history of COVID-19; group 2-135 patients who survived mild (n=85) or moderate COVID-19 (n=50) less than 12 months prior to Transvaginal Oocyte Retrieval (TOR). The new RNA Betacoronavirus SARS-CoV-2 in 2019 was the cause the first cases of COVID-19 in humans, and in March 2020 WHO announced a COVID-19 pandemic. SARSCoV- 2 infection can trigger such immunopathological mechanisms as inflammation, apoptosis, endothelial dysfunction, cytokine storm, complement and coagulation hyperactivation.