Journal des médicaments en développement
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Pharmacokinetics and toxicity challenges to delivery of cancer nanomedicines

Rakesh Dixit

Nanomedicines are increasingly being used to diagnose, prevent and treat human diseases. Nanotechno- logical advances are enabling targeted delivery of difficult to deliver innovative therapies, including gene editing and disease correcting gene delivery, highly lipophilic cytotoxic cancer drugs, mod RNA, etc. Although nanomedicines offer great opportunities for targeted delivery, they have increasingly faced safety, disposi- tion, CMC and manufacturing challenges that have limited their utility.