Journal de pharmacie appliquée
Libre accès

Abstrait

Partially Modified Potato Starch for Drug Delivery Applications

Roaa Mohammed*, Nizar Hadi, Ali Al-Zubiedy

Natural biopolymers are the most likely choice for biomedical applications. Starches consider the best materials for such applications. This came from the fact of their natural origin and the high biodegradable behavior. Native starches have weak hydrogen bonding make it not likely for drug delivery application as well as to leaching behavior. To make starch useful as drug delivery carrier, this hydrogen bonding must get stronger. In this work native sweet potato starch was used. The hydrogen bonding between starch molecules was enhanced by using glycerol as hydrogen bonding source and Sodium Alginate (SA) as thickener phase. This blend was tested using FTIR and DSC, depending on the test results, an improvement with hydrogen bonding was take place. A microfluidic capillary was used to form microspheres using total flow rates ranging from 0.00062 cm/sec-0.00031 cm/sec. The starch/SA/ glycerol was used as dispersed phase and PVA+tween 80 was used as continuous phase. Starch microspheres was successfully formed with diameter range from 151 μm-263 μm.