Journal des antiviraux et des antirétroviraux
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Optimizing Pediatric Antiretroviral Therapy Dosing Adherence and Outcomes

Nirantha Chaiyaporn*

Pediatric HIV management remains a pressing global health challenge, particularly in low and middle income countries. While antiretroviral therapy (ART) has significantly improved survival and quality of life, optimizing treatment in children requires careful attention to age appropriate dosing, adherence strategies, and outcome monitoring. Pediatric populations differ physiologically from adults, making pharmacokinetics, drug formulations, and behavioral interventions essential to therapy success. This article explores current challenges and advancements in pediatric ART, focusing on individualized dosing, factors influencing adherence, and long-term treatment outcomes. It emphasizes the need for integrated care models, caregiver education, and child-friendly drug formulations to enhance viral suppression and improve health trajectories for HIV-positive children. Keywords: Pediatric HIV; Antiretroviral therapy; ART adherence; Dosing challenges; Child-friendly formulations; Viral suppression; Pharmacokinetics; HIV outcomes; pediatric care; HIV resistance