Ingénierie enzymatique
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Olive oil’s polyphenols can protect against Type 2 Diabetes

Ali Chaari

The loss of b-cell function and b-cell death is key feature of type 2 diabetes (T2M). Different hypothesis is presented to contribute to this disease including amyloid formation by the human islet amyloid polypeptide (hIAPP). Despite the prevalence of T2M on the world, there are no therapeutic strategies for the treatment or prevention of amylin amyloidosis. Clinical trials and population studies indicate the healthy virtues of the Mediterranean diet especially the extra virgin olive oil enriched in phenolic compounds showed to be effective against several aging and lifestyle diseases including their action in relation of amyloid deposits related diseases. For this, oleuropein (Ole) one of the most abundant polyphenol in EVOOO, which has been reported to be also anti-diabetic, and some of its main derivatives, have attracted our interest due to their multitarget effects including the interference with amyloid aggregation path. However, the structure- function relationship of polyphenols Ole and its metabolites in T2DM are not yet clear.