Anatomie et physiologie : recherches en cours
Libre accès
ISSN: 2161-0940
ISSN: 2161-0940
Ibegbu O. Augustine, Okechukwu N. Gertrude , Orji O. Kenneth, Uchewa O. Obinna, Sarah Al-Rashed, Ezemagu K. Uchenna, Ibe Michael Usman, Egwu A. Ogugua, Gaber El-Saber Batiha
Background: Lead is deleterious to hematological, biochemical and hepatic parameters and researches have focused on antioxidants with therapeutic potentials to resolve and prevent these changes.
Objective: To study the influence of Ocimum Gratissimum (OG) extract on lead-induced hepatotoxicity and hemato-biochemical parameters of adult Wistar rats.
Methodology: Thirty-five adult Wistar rats were assigned into seven groups of five rats each. Group A served as Control, B received 120 mg/kg of lead while C received 375 mg/kg of OG. Groups D and E received 120 mg/kg of lead before 375 mg/kg and 750 mg/kg of OG respectively. Group F received 375 mg/kg of OG extract then 120mg/kg of lead while Group G received 120 mg/kg of lead and 1,190 mg/kg of ascorbic acid. All administrations lasted for 21 days orally, after which the animals were sacrificed; blood and liver tissues were collected for biochemical and histological analysis.
Results: The result showed increase in the mean body weight in the Control but a decrease in B. The result of biochemical analyses showed significant increase in Liver enzymes namely: ALT, AST, GGT and ALP in Group B compared to the Control and other treatment groups (p ≤ 0.05). The result of histological analysis of the liver tissues showed degenerative changes with focal necrosis and aggregated inflammatory cells in B and liver treated with the extract showed ameliorative changes as in Groups (D-G).
Conclusion: The extract of OG could be used as a therapeutic agent for intervention in lead poisoning.