Journal d'immunologie clinique et cellulaire
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Non-Secretory Multiple Myeloma with Lytic Bone Lesions about a New Observation

Mounira El Euch, Fatma Ismail Ben Fredj, Amel Rezgui, Monia Karmani, Fatma Derbeli, Raja Amri and Chedia Laouani Kechrid

Non-excretory myeloma is a rare variety of multiple myeloma in which classical techniques of research of the stigmata of chronic secretion fail to highlight the monoclonal peak or proteinuria of Bence Jones. Lytic bone lesions are rare in this type of myeloma. We report the case of a patient in whom we confirmed multiple myeloma by bone marrow aspiration and we have classified stage III of Durie and Salmon in view of hypercalcemia, anemia, and lytic lesions observed. However, we could not isolate a secretion of monoclonal immunoglobulin in blood but urinary secretion was evident by proteinuria and urinary light chains. The radiographs of our patient were highly suggestive of osteolysis seen diffuse the practice of sternal puncture has emerged even in the absence of criteria such as blood secretion highlighting the monoclonal peak in serum protein electrophoresis or the quantitation of immunoglobulins. Our case original seen that the diffuse osteolytic lesions were often observed within the secretory disease and rarely in the form of non-secreting.