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Nicolau Syndrome: A Devastating Injection Site Drug Reaction

Pooja Manwar, Sumit Kar*, Ajinkya K Sawant, Subhor Nandwani, Safa Patrick

Nicolau syndrome is a severe iatrogenic injection site drug reaction. Here, we present a case of 43 year old female patient with Nicolau syndrome 2 days following intramuscular injection of diclofenac sodium in the right gluteal region. No diagnostic criteria have been proposed yet, diagnosis is usually clinical. Symptomatic treatment along with debridement and dressing is generally advised. Nicolau syndrome traditionally described as embolia cutis medicamentosa or livedoid dermatitis which is easily identifiable by history, clinical findings and course.