Journal de pharmacie appliquée
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NEUROTOXIC EFFECT OF CIPROFLOXACIN ON ALBINO RAT

Sayed M Rawi, Nasser M. Alshibly and Fatema Seif El-Nasr

Flouroquinolones are one of the most commonly used antibacterial antibiotics for the treatment of various infections throughout several mechanisms. The CNS side effects, however, which is the molecular target organ is still not exactly known under therapeutic and higher dose exposure. Therefore, the objective of this study was to explore the neuronal biochemical effects of ciprofloxacin at different doses. Five groups of Sprague Dawley rats (150-170 g) were employed; one received 20 mg/kg/24 hours for 14 days and the others were received a single oral dose of either 50,100,200 or 300 mg/kg and decapitated post 24 hours. At the therapeutic dose level, ciprofloxacin was significantly lowered whole brain total protein, glutamate, GABA, glycine and alanine and increased aspartate, taurine, histidine and serine. At the same dose level, brain serotonin, AChE, Na+, K+-ATP-ase, plasma total protein and glucose were decreased. Reduced-GSH was decreased and oxidized-GSH was increased in the studied brain areas. Noradrenaline and dopamine were decreased only in cerebral cortex and increased in the hippocampus. At the higher tested doses, there was a vigorous similar pattern effect on the concentration of the whole-brain amino acids, and the higher potent effect was attained at 200 and 300 mg/kg dosing groups.