Journal de la nanomédecine et de la découverte biothérapeutique
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Nanoparticles and DNA damage

Thomas Prevenslik

Nanoparticles or NPs are known to cause DNA damage for over at least the past decades, but the causal relation of NPs to human health remains unknown. Chemical reactions of NPs with the DNA cannot be the causal relation as DNA damage occurs even with inert gold NPs suggesting a physical causal relation such as high temperature. Photodynamic therapy is thought to kill cancer cells by high temperatures in laser heating of NPs. Although the laser increases the temperature of surrounding tissue, the NP temperature itself does not because the Planck law of QM requires the NP heat capacity to vanish. QM stands for quantum mechanics. Contrarily, photodynamic therapy does not induce necrosis of cancers by increasing the temperature of the quantum sized NPs and instead NPs produce EM radiation beyond the UV that induces cancer necrosis suggesting the causal relation of NPs to human health is therefore the well-known genotoxicity of DNA to UV radiation. The wavelength ? of the emitted EM radiation is, ?= 2nd, where n and d are the refractive index and diameter of the NP. For NPs having n=1.5, DNA damage for EM radiation beyond the UVC (?< 254 nm) occurs for NP diameters d